Stem cells

The complexity of the neuronal connections is formed during development under the guidance of both genetic and environmental factors. The interplay between genetic blueprint and neuronal activity results in formation of synaptic connections pattern, unique for each individual. Genetic or environmental alterations in this process may push developing network towards pathological attractor state, leading to progression of a neurodevelopmental disorder.

My research has investigated neurobiology of neurodevelopmental disorders, especially autism spectrum disorder, using fragile X syndrome (FXS) as a model disease. We have shown that the absence of FMR1 protein affects differentiation of human and mouse FXS neural progenitors leading changes in calcium dynamics and functional responses of differentiated neuronal cells.